在埃塞俄比亚接受结核病治疗的人群中,智能药盒坚持干预的参与度较差的风险因素
Amare Worku Tadesse1, Martina Cusinato2,3, Gedion Teferra Weldemichael4
1TB Centre, Department of Infectious Disease Epidemiology, London, School of Hygiene & Tropical Medicine (LSHTM) , London, UK. amare.tadesse@lshtm.ac.uk.
BMC public health
|October 14, 2023
概括
像智能药盒这样的数字坚持技术可以改善结核病治疗. 然而,诸如社会经济地位较低,艾滋病毒阳性状况,单身生活或寡居等因素与埃塞俄比亚对这些工具的参与度较低有关.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 数字健康数字健康
背景情况:
- 不遵守结核病 (TB) 治疗可能会导致严重的不良后果.
- 数字坚持技术 (DATs),如EvriMED智能药盒,越来越多地被评估以提高结核病治疗的坚持.
- 这项研究是结核病终结坚持支持联盟 (ASCENT) 项目的一部分,调查了影响智能药盒参与的因素.
研究的目的:
- 分析埃塞俄比亚一个集群随机试验的数据,以确定与药物敏感结核病 (DS-TB) 患者中智能药盒接触不良的个人层面因素.
- 了解社会经济地位,艾滋病毒状况和婚姻/生活状况如何影响使用数字坚持技术.
主要方法:
- 分析了2020年12月至2022年5月期间使用智能药盒的1262名DS-TB参与者的数据.
- 低参与度被定义为>20%没有数字确认的日数和56天和168天期间没有确认的日数.
- 用物流和负二项式随机效应回归模型来解释设施级聚类.
主要成果:
- 在56天的时间里,10.8%的参与者表现出不良参与;在168天的时间里,这一数字上升到15.8%.
- 更高的社会经济地位与超过56天的更好的参与度有关.
- 艾滋病毒阳性状态,单身/独立生活状态和离婚/寡妇状态与较高的剂量未确认率显著相关.
结论:
- 较低的社会经济地位,艾滋病毒阳性状况和特定的社会/生活环境 (单身,分居,寡居) 与埃塞俄比亚DS-TB患者对智能药盒的参与度较低有关.
- 针对这些子组量身定制的差异化护理策略可能对减轻结核病治疗不依附的风险至关重要.
- 研究结果强调,在实施结核病治疗的数字坚持技术时,需要考虑个体患者的因素.
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