与脂肪代谢相关的tRNA衍生小RNA的转录组的动态变化
Tianci Liao1,2, Mailin Gan1,2, Yuhang Lei1,2
1Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, 611130, China.
Scientific data
|October 14, 2023
概括
肥胖是一个日益严重的全球健康问题. 这项研究确定了猪和小鼠脂肪组织中tRNA衍生小RNA (tsRNA) 的新型,为脂肪沉积调节提供了新的见解.
科学领域:
- 生物化学 生物化学
- 遗传学 是一个遗传学.
- 分子生物学分子生物学
背景情况:
- 全球肥胖和超重的流行率不断上升,对健康构成了重大挑战.
- 脂肪组织的异常积累是肥胖的主要原因,许多调节机制尚未完全理解.
- tRNA衍生小RNAs (tsRNAs) 正在成为各种生物过程中的关键调节者.
研究的目的:
- 在不同类型的猪和小鼠脂肪组织中识别和描述tsRNA.
- 探索tsRNAs在脂肪沉积的表观遗传调节中的潜在作用.
- 为未来关于肥胖和代谢障碍的研究提供有价值的数据集.
主要方法:
- 小RNA测序是在瘦肉和肥胖猪的皮下和口腔白色脂肪组织上进行的.
- 从正常小鼠的头皮棕色脂肪组织 (BAT), inguinal白色脂肪组织 (iWAT) 和 epigonadal白色脂肪组织 (eWAT) 中生成tsRNA配置文件.
- 生物信息分析用于识别不同脂肪组织类型和物种表达的tsRNA和保存的tsRNA.
主要成果:
- 在每个分析的脂肪组织类型中确定了大量的表达的tsRNAs.
- 在猪和小鼠的各种脂肪组织中确定了保存的tsRNA.
- 该研究成功地为不同脂肪组织生成了全面的tsRNA表达配置文件.
结论:
- 已识别的tsRNAs代表了一种参与调节脂肪沉积的新型分子类.
- 这些发现有助于理解导致肥胖的表观遗传机制.
- 生成的数据集将成为未来对脂肪组织生物学和代谢疾病的研究的宝贵资源.
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