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脑血流中的psilocybin诱导的变化与急性和基线个人间的差异有关

Nathalie M Rieser¹, Ladina P Gubser², Flora Moujaes^2,3

¹Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital Zurich, Lenggstrasse 31, Zurich, Switzerland. nathalie.rieser@bli.uzh.ch.

Scientific reports

|October 14, 2023

概括

这种药物是psilocybin.

科学领域:

神经科学是一个神经科学.
心理药理学心理药理学
放射学放射学是一门学科.

背景情况:

对精神疾病的psilocybin研究正在扩大.
关于 псилоцибин影响的大脑行为联系尚未得到充分证实.
对西的反应的个体差异尚不清楚.

研究的目的:

为了研究psilocybin对大脑血流 (CBF) 的影响.
探索神经变化,主观经验和基线特征之间的关系.
为了了解 псилоцибин急性神经效应的个体变异性.

主要方法:

健康的参与者 (N=70) 接受了口服 псилоцибин剂或安慰剂.
动脉旋转标签被用于测量相对和绝对CBF.
探索性分析检查了与基线特征和主观经验的关联.

主要成果:

西宾的使用改变了相对和绝对CBF.
基线心理和神经生物学特征与CBF变化和主观经验相关联.
主观的迷幻效应与急性CBF变化有关.

结论:

神经对 псилоцибин反应的个体间差异与基线特征有关.
这些发现揭示了psilocybin诱导的改变状态的机制.
结果支持心理辅助疗法和生物标志物发现中的个性化医疗方法.

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