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抗菌Fe₂O₃-CuO-P₂O₅的眼镜可以使用

Alexandra L Mitchell¹, Sung Hoon Lee², David J McEnroe³

¹Corning Incorporated, 1 Riverfront Plaza, Corning, NY, 14831, USA. mitchellal@corning.com.

Scientific reports

|October 14, 2023

概括

开发了新的抗微生物眼镜,以防止疾病在医院传播. 增加氧化铁 (Fe2O3) 增加了耐久性,但通过限制铜释放,降低了抗菌效果.

科学领域:

材料科学材料科学材料科学
无机化学无机化学
生物医学工程生物医学工程

背景情况:

传染病的虫媒介传播在高风险环境中是一个重大问题.
现有的抗微生物材料可能缺乏适用于苛刻应用的必要耐用性.
探索Fe2O3-CuO-P2O5三元系统,以开发耐用的抗微生物眼镜.

研究的目的:

开发具有高抗微生物功效的眼镜,以减轻疾病传播.
通过添加Fe2O3.3来增强抗菌玻璃的化学耐用性.
为了研究玻璃成分,耐久性和抗菌性质之间的关系.

主要方法:

在Fe2O3-CuO-P2O5三元系统中合成玻璃.
评估化学耐用性和铜离子浸出.
使用日志杀伤测试进行抗菌疗效测试.
Ab-initio分子动力学模拟以了解结构性质.

主要成果:

添加Fe2O3显著增加了玻璃的化学耐用性,减少了铜液超过3个数量级.
最高的Fe2O3含量,同时最大限度地提高了耐用性,导致抗菌疗效低于目标日志杀伤.
分子动力学模拟表明网络连接性增加,Fe2O3含量更高.
实验结果证实Fe2O3含量,而不是CuO,决定了铜的释放和抗菌活性.

结论:

添加Fe2O3对于提高基于CuO-P2O5的抗菌玻璃的耐用性至关重要.
为了耐用性,需要在Fe2O3含量和CuO含量之间保持平衡,以获得抗菌效果.
化铜的数量,而不是其氧化状态,是抗菌活性的主要驱动因素.

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