咖啡因摄入量和被动吸烟对带血单位质量参数的影响
Walid Almashaqbeh1,2, Husam Ardah3, Amal Alasmari4
1Saudi Stem Cell Donor Registry and Cord Blood Bank, King Abdullah International Medical Research Center, College of Science and Health Professions, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.
Cell and tissue banking
|October 15, 2023
概括
孕妇的咖啡因消费显著降低了带血 (CB) 干细胞的质量和数量. 被动吸烟对带血干细胞指标没有显著影响.
科学领域:
- 血液学 血液学 血液学
- 干细胞生物学 干细胞生物学
- 公共卫生 公共卫生
背景情况:
- 带血 (CB) 是血液造血干细胞的重要来源,用于治疗血液学疾病.
- 结核细胞利用的局限性源于核细胞数量的减少,因此需要改善供体选择和库存质量的策略.
- 了解影响CB质量的因素对于最大限度地提高干细胞采集效益至关重要.
研究的目的:
- 为了研究被动吸烟和母亲咖啡因消费对带血质量的影响.
- 分析影响带血干细胞参数的孕产妇和新生儿因素.
- 为优化带血储存策略和公共卫生意识提供数据.
主要方法:
- 在得到知情同意后,在国王阿卜杜拉齐兹医疗城从母亲那里收集了带血单位.
- 母亲采访收集了有关人口统计,吸烟暴露和咖啡因摄入量的数据,并补充了图表评论.
- 实验室测试评估了带血核细胞计数 (MNC),淋巴细胞水平和干细胞功效 (CFU,BFU-E).
主要成果:
- 母亲的咖啡因消费与带血MNC的显著减少有关,包括淋巴细胞.
- 咖啡因摄入也导致干细胞功率下降,由较低的总CFU和BFU-E数量证明.
- 被动吸烟暴露对测量的带血质量参数没有显著影响.
结论:
- 孕产妇的咖啡因消耗会对带血干细胞产量和功效产生负面影响.
- 在这个队列中,被动吸烟对带血质量的影响没有统计学意义.
- 研究结果强调需要提高孕妇对咖啡因摄入的认识,以保持带血干细胞质量.
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