在牛皮性关节炎中,secukinumab诱导的全身性红斑狼
Pedro Ávila-Ribeiro1, Ana Rita Lopes1, Joana Martins-Martinho1
1Rheumatology and Metabolic Bone Diseases Department, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisbon Academic Medical Center, European Reference Network on Rare Connective Tissue and Musculoskeletal Diseases Network.
ARP rheumatology
|October 15, 2023
概括
在一个牛皮关节炎患者中,secokinumab的重新引入引发了药物诱导的红性狼 (DILE),呈现出全身和的参与. 早期诊断和治疗导致完全缓解,突出了DILE作为潜在的secukinumab副作用.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 塞库金努马布是一种互乐金-17A抑制剂,用于治疗牛皮关节炎.
- 药物诱导性红斑狼 (DILE) 是各种药物的罕见副作用.
- 这个案例探讨了secukinumab和DILE之间的潜在关联.
研究的目的:
- 报告与secukinumab相关的全身DILE病例.
- 为了突出第一个被记录的脏参与secukinumab相关DILE的案例.
主要方法:
- 一份病例报告显示,一名68岁的男性患有牛皮性关节炎,接受了secukinumab治疗.
- 记录了临床表现,实验室调查,成像和治疗反应.
- 文献综述将此病例与之前报告的DILE.病例进行比较.
主要成果:
- 患者出现了与DILE一致的症状,包括发烧,疲劳,关节痛,细胞衰竭,阳性抗核和抗dsDNA抗体以及蛋白尿.
- 在胸部成像中观察到肺栓塞,肺炎和肺.
- 停止使用secuquinumab并开始免疫抑制疗法导致临床和实验室缓解,持续蛋白尿.
结论:
- 该病例是第二次报告与secukinumab相关的全身DILE,也是第一次涉及狼性炎.
- 塞库金纽马布应该被认为是DILE的潜在原因,需要对全身和脏表现进行警监测.
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