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分子奇拉尔 mesoporous纳米颗粒的Enantioselective口服吸收
Yuxin Wang1,2, Lin Zhao1, Yibo Dai1
1School of Pharmacy, China Medical University, Shenyang, 110122, China.
Advanced materials (Deerfield Beach, Fla.)
|October 15, 2023
概括
性显著增强纳米载体的口服吸附. 与achiral或racemic版本相比,L-酸修饰的半孔纳米颗粒 (l-CMSNs) 显示出优异的粘液透,细胞吸收和药物输送.
科学领域:
- 纳米技术纳米技术
- 材料科学 材料科学 材料科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 奇拉药物在生物系统中表现出独特的效果.
- 纳米载体的特性,如尺寸和形状,会影响口服吸附.
- 纳米载体性在口服吸附效率中的作用尚未被探索.
研究的目的:
- 为了调查纳米载体性是否影响口服吸附效率.
- 为了制造和评估性中等孔纳米颗粒 (CMSNs).
- 为了比较口服吸收的奇拉,racemic和achiral纳米载体.
主要方法:
- 通过一共凝结制造1 / d-酸修饰的半孔性纳米粒子 (l / d-CMSNs).
- 口服吸收过程的顺序评估:粘液透,生物粘附,细胞吸收,肠道运输和GIT保留.
- 通过实验和理论方法分析状识别机制.
- 在体内评估纳米载体吸收,药物输送,生物可用性和治疗疗效.
主要成果:
- 与d-CMSN,dl-CMSN和MSN相比,l-CMSN在所有口服吸收步骤中表现优越.
- 确定了以静电相互作用为主导的状识别机制.
- l-CMSNs显示显著更高的血液吸收 (1.72-2.05倍).
- 药物载荷的l-CMSN改善了肠道运输 (2.32-27.03倍),生物可用性 (449.73%) 和抗瘤作用 (高达95.43%).
结论:
- 纳米载体性是控制口服吸附和生物命运的关键因素.
- l-CMSN为多克索鲁比辛 (DOX) 等药物提供了增强的口服输送潜力.
- 状纳米载体是改善药物输送和治疗结果的有希望的策略.
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