奇亚里网络和尤斯塔基亚门对中风的秘密影响:一个范围审查和元分析
Mohammed Q Al-Sabbagh1, Prasanna Eswaradass
1Department of Neurology, University of Kansas Medical Center, Kansas City, KS.
The neurologist
|October 15, 2023
概括
奇亚里网络 (CN) 和欧斯塔基亚 (EV) 在中风患者中常见,这些患者有状孔 (PFO). 这些发现增加了心血管栓塞性中风风险,并应被视为高风险的PFO特征.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 血管医学 血管医学
背景情况:
- 基亚里网络 (CN) 和尤斯塔基亚 (EV) 与心血管栓塞性中风之间的关联仍然不清楚.
- 对于管理这些病变以减轻中风风险,存在不一致的临床方法.
研究的目的:
- 描述中风患者中NC和EV的临床表现,神经成像和心脏成像特征.
- 在中风的背景下概述CN和EV的管理策略.
主要方法:
- 使用PubMed和Web of Science,按照PRISMA指南进行了系统的文献搜索.
- 包括4个病例控制研究,2个横截面研究和8个病例报告,共883名患者.
- 诊断CN/EVs主要使用过食道心声学或心内心声学.
主要成果:
- 脑中风患者中EVs/CN的综合患病率为50%,这些患者有 patent foramen ovale (PFO).
- 单独发病率为43%的EV和18%的CN.
- 患有中风病史的患者表现出更高的EVs/CN流行率 (OR=2.45,P<0.01).
结论:
- EV和CN在PFO中风患者中很常见,似乎会增加心血管血栓性中风风险.
- 这些发现未得到充分承认,应该被认为是高风险的PFO特征.
- 需要进一步的研究,以指导临床决策,对这些患者的PFO关闭和抗血栓治疗.
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