经过外科手术后的血栓性并发症 血栓性并发症 经过外科手术后的血酸给药
Ella C Eisinger1, Liam Forsythe2, Sarah Joergensen2
1Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
The Journal of surgical research
|October 15, 2023
概括
在创伤患者中,经验上使用的松酸 (TXA) 没有增加死亡率或静脉血栓塞栓症 (VTE). 然而,TXA的使用与更高的输血量有关,这表明其安全性,但需要进一步研究以定向应用.
科学领域:
- 创伤护理的护理人员.
- 药理学 药理学是指药理学的学科.
- 关键护理医学 关键护理医学
背景情况:
- 抗纤维解氧化特兰胺酸 (TXA) 在创伤中用于减少死亡.
- 它在未经证实过敏纤维素分解的患者中的使用及其与并发症的关联仍然不清楚.
研究的目的:
- 在创伤患者中分析经验管理的TXA的关联.
- 确定TXA使用是否与输血量较低和血栓栓塞并发症增加相关.
主要方法:
- 创伤患者的大规模输血协议 (2016-2021) 的回顾性队列研究.
- 接受TXA治疗的患者与未接受TXA治疗的患者的比较.
- 主要结局:住院死亡率. 二次结局:静脉血栓塞栓症 (VTE),输血量,凝血措施.
- 统计分析包括描述性统计,单变量分析和多变量逻辑回归.
主要成果:
- TXA患者呈现较低的缩血压,较高的损伤严重程度得分,并且更有可能接受紧急手术.
- 在调整后,TXA与死亡率或VTE没有显著关联.
- 在4小时和24小时内,TXA患者获得了大量的红细胞,血小板和血.
- 通过血栓elastography.没有观察到凝块稳定性的差异.
结论:
- 在创伤患者的实证TXA管理与增加的死亡率或VTE无关.
- 使用TXA与更高的输血需求有关,可能是由于更严重的出血.
- 在这个群体中TXA的安全性支持其使用,但需要进一步的研究来优化其应用.
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