在以反为重点治疗的认知行为情绪调节训练期间的现场fNIRS测量:一个随机对照试验
Hendrik Laicher1, Isabell Int-Veen1, Leonie Woloszyn1
1Department of Psychiatry and Psychotherapy, University Hospital of Tuebingen, Tübingen Center for Mental Health (TüCMH), Tuebingen, Germany; German Center for Mental Health (DZPG), partner site Tuebingen, Germany.
NeuroImage. Clinical
|October 15, 2023
概括
基于正念的情绪调节训练 (MBERT) 有效地减少了抑郁的反. 这项研究观察到,在MBERT期间,关键的认知控制区域的大脑活动增加,这表明它在严重抑郁症中具有治疗作用的神经基础.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 临床心理学 临床心理学
背景情况:
- 重复的负面思维 (RNT),包括反,是许多精神病理的核心.
- 了解心理治疗的神经基础,特别是RNT,仍然是研究中的一个重大差距.
- 功能近红外光谱 (fNIRS) 提供了一种在治疗干预过程中对神经相关的现场调查方法.
研究的目的:
- 评估fNIRS适应的基于正念的情绪调节训练 (MBERT) 的疗效,用于治疗患有严重抑郁症 (MDD) 的人的抑郁性反.
- 通过检查干预期间在认知控制网络 (CCN) 内的皮质活动来探索MBERT的神经相关物.
主要方法:
- 进行了一项随机对照试验,采用交叉设计,涉及42名被诊断为MDD的受试者.
- 心理测量措施,主观评分和fNIRS被用来评估抑郁症状严重程度,反和皮质活动的变化.
- 皮质活动在CCN中专门分析了双边下额回 (IFG) 和背侧前额皮质 (DLPFC) 的皮质活动.
主要成果:
- MBERT在减少抑郁症状和反思想方面表现出显著的有效性.
- 与对照条件相比,fNIRS在MBERT期间在双边IFG和DLPFC中显示出持续更高的皮质激活.
- 一个值得注意的发现是,在双边DLPFC内,皮质氧化在会话中减少,这表明了适应性神经变化.
结论:
- MBERT是MDD中抑郁性反的有效干预措施,支持神经活动的可观测变化.
- 该研究强调了认知控制网络,特别是IFG和DLPFC在MBERT的治疗机制中的作用.
- 需要进一步的研究,以充分阐明这些神经发现对MDD心理治疗的含义.
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