与对照组相比,白天和夜间的警觉性和昼夜功能
Denise Bijlenga1, Rolf Fronczek1, Evelyn J Gorter2
1Stichting Epilepsie Instellingen Nederland (SEIN), Sleep-Wake Centre, Heemstede, Netherlands; Leiden University Medical Center (LUMC), dept. Neurology, Leiden, Netherlands.
Epilepsy research
|October 15, 2023
概括
与白天和健康个体相比,夜间显著降低了警,增加了疲劳. 这表明醒觉时间质量较差,与昼夜节律中断无关.
科学领域:
- 神经学 神经学
- 睡眠医学 睡眠医学
- 的研究研究.
背景情况:
- 经常导致白天警问题和疲劳.
- 夜间发作可能会扰乱睡眠,导致这些白天的问题.
研究的目的:
- 在成年人与 (夜间与白天的发作) 和健康对照中比较警和昼夜标记.
- 识别导致中白天警觉性受损的因素.
主要方法:
- 包括30名患有的成年人 (夜间15次,白天15次) 和15名健康对照.
- 评估的主观嗜睡 (ESS),疲劳 (FSS),睡眠质量 (PSQI) 和时间型 (MCTQ).
- 测量客观警 (SART) 和昼夜功能 (PIPR).
主要成果:
- 组报告的疲劳 (FSS) 和警觉错误 (SART) 比对照组更高.
- 夜间发作组在FSS和SART分数中表现出最明显的缺陷.
- 夜间发作和增加抗发作药物的使用与较高的SART错误相关.
结论:
- 夜间与警觉性降低和清醒时间质量降低有关.
- 循环节功能障碍没有被确定为这些警问题的原因.
- 进一步的研究应该调查夜间中警觉问题的干预措施.
相关概念视频
01:15Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
69
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
69
02:19Circadian Rhythms and Gene Regulation
4.1K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.1K
01:07Narcolepsy
119
Narcolepsy is a chronic sleep disorder characterized by pervasive, uncontrolled sleepiness and other sleep disturbances. One of its hallmark symptoms is an abrupt transition to REM sleep upon falling asleep, which causes symptoms typically associated with this phase to occur unexpectedly during wakefulness. These include the following symptoms, which typically last from a minute or two to half an hour.
119
01:13Seizures: Classification
378
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
378
01:24Sleep-Wake Cycles
1.4K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
1.4K