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脊髓灰质炎中脑血管疾病的谱:一个病例系列和系统审查
Michela Rosso1, Srinath Ramaswamy2, David Aharonoff3
1Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Cerebrovascular diseases (Basel, Switzerland)
|October 15, 2023
概括
硬化皮质与脑血管疾病 (CBVD) 的更高风险有关,包括中风. 这项研究详细介绍了多样化的CBVD类型在硬化皮肤病患者,强调缺血性中风是最常见的.
科学领域:
- 神经学 神经学
- 类风湿病学 类风湿病学
- 血管医学 血管医学
背景情况:
- 从历史上看,中枢神经系统在硬化皮肤病 (SCL) 中的参与被低估了.
- 新出现的证据表明,SCL可能会增加脑血管疾病 (CBVD) 风险,独立于传统因素.
- 这项研究调查了SCL患者中CBVD的临床谱.
研究的目的:
- 描述在硬化皮质症中CBVD的临床,人口,实验室和放射性发现.
- 系统地审查关于系统性硬化症中脑血管疾病的文献.
- 为了增强对硬化皮肤病和CBVD之间的关系的理解.
主要方法:
- 编制了35年来患有CBVD的多样性硬化症患者的病例系列.
- 通过使用MEDLINE,Embase和WoS数据库进行了系统的文献审查.
- 分析了110项已确定研究的数据,其中包括93名具有患者级数据的患者.
主要成果:
- 病例系列包括14名患者 (85%为女性,平均年龄为48岁);缺血性中风是最常见的CBVD (64%).
- 系统性审查分析了来自82份报告的93名患者 (79%为女性,平均年龄为48岁).
- 缺血性中风 (29%),血管病 (20%) 和出血 (12%) 是研究中发现的最常见的CBVD类型.
结论:
- 硬化症与多种脑血管疾病有关,急性缺血性中风占主导地位.
- 发病可能涉及慢性炎症,自身免疫和内皮功能障碍的复杂相互作用.
- 这一综述强调了硬质皮症作为早期发生的CBVD的潜在风险因素,为临床意识提供了信息.
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