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放射学隔离综合征 放射学隔离综合征

Christine Lebrun-Frenay1, Orhun Kantarci2, Aksel Siva3

  • 1CRC-SEP Nice, Neurologie CHU Nice, Hôpital Pasteur 2, UMR2CA-URRIS, Université Côte d'Azur, Nice, France.

The Lancet. Neurology
|October 15, 2023
PubMed
概括
此摘要是机器生成的。

放射性隔离综合征 (RIS) 可能表明多发性硬化症的症状前阶段. 早期使用免疫调节药物的治疗显示出在高危人群中预防临床转换的前景.

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科学领域:

  • 神经学 神经学
  • 放射学 放射学是一门学科.
  • 免疫学 免疫学 免疫学

背景情况:

  • 放射性隔离综合征 (RIS) 的特点是偶尔出现暗示多发性硬化症 (MS) 的脱髓化病变,但没有临床症状.
  • 纵向数据表明,大约50%的RIS患者在10年内发展为症状性MS,这表明RIS可能是MS的前症状阶段.

研究的目的:

  • 审查目前对放射性隔离综合征 (RIS) 和其进展到多发性硬化症 (MS) 的理解.
  • 确定RS患者中MS发展的风险因素和潜在生物标志物.
  • 评估早期免疫调节治疗在预防RIS临床转化中的有效性.

主要方法:

  • 关于RIS进展的国际纵向队列数据的审查.
  • 风险因素的分析,包括年龄,性别,脑脊液 (CSF) 的橄克隆带,病变位置和加多增强.
  • 评估了两项针对RIS的免疫调节疗法随机临床试验的数据.

主要成果:

  • 临床MS进展的关键风险因素包括年龄较小 (<35岁),男性性别,中枢神经受限的橄克隆性带,脊髓/骨底病变和加多增强病变.
  • 两项临床试验表明,经批准的多发性硬化症免疫调节药物可以在2年内在一些RIS患者中预防临床转化.

结论:

  • RIS代表了多发性硬化症的潜在前症状阶段,具有可识别的进展风险因素.
  • 使用免疫调节疗法的早期干预可能会改变RIS高风险个体的疾病进程,可能会改变患者的护理.