暴露于不同氧化多环芳的瘤细胞的代谢调节

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Rui Gao¹, Zihao Jiang², Xiuyu Wu³

¹School of Forensic Medicine, Shanxi Medical University, Jinzhong 030600, PR China; College of Environment and Resource, Research Center of Environment and Health, Shanxi University, Taiyuan, Shanxi 030006, PR China.

The Science of the total environment

|October 15, 2023

概括

某些含氧多环芳 (OPAH) 通过影响细胞运动和血管生长来促进癌症. 它们的促进瘤的作用与氧化应激和改变的谷氨代谢有关.

科学领域:

环境化学环境化学
毒理学毒理学毒理学
分子生物学分子生物学

背景情况:

氧化多环芳 (OPAH) 是多环芳的衍生物,具有含氧功能组.
已知OPAH诱导氧化应激和突变,但它们的致癌和代谢作用尚不清楚.
关于OPAHs导致癌症发展的具体机制的研究有限.

研究的目的:

调查四种不同OPAHs的致癌作用.
探索OPAHs在促进细胞入侵,转移和血管生成中的作用.
了解OPAH致癌性及其对细胞代谢,特别是谷氨代谢的影响之间的关系.

主要方法:

分析了四种OPAHs的致癌作用:9-氨 (FLO),9,10-氨 (AQ),7,12-氨 (BAQ) 和1,8-纳酸 (NAD).
评估OPAH诱导的上皮层-介质酶过渡 (EMT),以评估细胞入侵和转移.
通过分析血管内皮生长因子 (VEGF),血管蛋白质 (ANG) 和血小板衍生生长因子 (PDGF) 的表达来测量内皮细胞血管生成.
整合代谢分析,将OPAH影响与代谢途径联系起来,重点关注谷氨代谢和氧化应激.

主要成果:

9-氨 (FLO),9,10-氨 (AQ) 和7,12-氨 (BAQ) 通过EMT显著促进细胞入侵和转移.
这三种OPAH还通过改变VEGF,ANG和PDGF的表达来诱导内皮细胞血管生成.
1,8-纳酸 (NAD) 没有显著的致癌作用.
代谢分析显示,OPAHs的促进瘤活动与它们对代谢的影响有关,特别是谷氨代谢和氧化应激.

结论:

特定的OPAHs (FLO,AQ,BAQ) 具有致癌性,驱动转移和血管生成等关键过程.
OPAHs的致癌作用与它们对细胞氧化应激和谷氨代谢的影响有机联系.
这些发现为进一步研究OPAH致癌性和风险评估提供了基础.

关键词:

血管新生的产生.在EMT中,EMT是EMT.代谢调节代谢调节代谢调节有氧化多环芳香碳化合物.瘤是一个瘤.

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