氧化:关键的治疗进展和癌症缓解的新兴纳米技术景观
Liang Ee Low1, Chee Kei Kong2, Wei-Hsum Yap3
1Department of Chemical Engineering, School of Engineering, Monash University Malaysia, Jalan Lagoon Selatan, 47500, Bandar Sunway, Selangor Darul Ehsan, Malaysia; Advanced Engineering Platform, Monash University Malaysia, Jalan Lagoon Selatan, 47500, Bandar Sunway, Selangor Darul Ehsan, Malaysia; Monash-Industry Plant Oils Research Laboratory (MIPO), Monash University Malaysia, Jalan Lagoon Selatan, 47500, Bandar Sunway, Selangor Darul Ehsan, Malaysia.
氧氨酸 (HCQ) 通过抑制瘤自性,在癌症治疗中表现有前途. 纳米技术的整合增强了HCQ.
科学领域:
- 在瘤学瘤学.
- 纳米医学是一种纳米医学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 基 (HCQ) 正在探索用于癌症治疗,抑制瘤微环境诱导的自.
- 临床前数据表明,HCQ通过使瘤细胞敏感,增强了传统治疗的效果.
- 临床使用面临挑战:分布不良,溶解性,生物可用性和视网膜毒性.
研究的目的:
- 审查HCQ的药理动力学,药理动力学和抗瘤特性.
- 评估纳米配方HCQ的增强抗瘤性能.
- 以指导使用基于HCQ的纳米药物改进的癌症治疗策略.
主要方法:
- 对癌症中HCQ的临床前和临床研究的综述.
- 对基于纳米技术的HCQ交付方法的分析.
- 对药理动力学,药理动力学和毒性概况的评估.
主要成果:
- HCQ在癌症中表现出二分法作用,抑制自但面临临临床限制.
- 纳米技术为HCQ的可溶性,生物利用性和毒性差的解决方案提供了解决方案.
- 纳米封装/纳米结合提高了HCQ的抗瘤疗效和安全性.
结论:
- 纳米配制的HCQ为克服传统HCQ疗法的局限性提供了一个有希望的策略.
- 纳米技术提高了HCQ的治疗指数,改善了癌症治疗结果.
- 本综述为开发用于瘤学的基于HCQ的先进纳米药物提供了一份指南.
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