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在由聚烯二衍生过器中对卡斯波金的隔离:增加剂量不会减轻隔离的作用.

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在连续脏替代疗法期间,增加卡斯波金的剂量并不能阻止其在多烯二烯过器中被封存. 这突显了使用卡斯波金与这些过器的风险,建议使用替代抗真菌剂或疗法.

关键词:
在Caspofungin中使用.持续的替代疗法 持续的替代疗法埃奇诺坎迪因 (echinocandins) 是一种类型.药理动力学 药理动力学扣留 扣留 扣留 扣留 扣留治疗失败 治疗失败

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科学领域:

  • 药理学 药理学是指药理学的学科.
  • 腎臟病學 (nephrology) 是一種醫學專業.
  • 临界护理医学 临界护理医学

背景情况:

  • 持续置换疗法 (CRRT) 对重症患者至关重要.
  • 埃奇诺坎丁和卡斯波丁一样,是治疗白血病的第一线治疗方法.
  • 预先的数据显示,埃奇诺坎丁在多烯二过器中被封存.

研究的目的:

  • 调查增加卡斯波金剂量是否可以克服聚烯二烯过器中的封存.
  • 为了评估CRRT过器对卡斯波金排放的影响.

主要方法:

  • 在体外使用STX过器 (多烯) 的研究.
  • 使用液体染色学-质谱学测量的卡斯波金度.
  • 使用NeckEpur技术在晶体介质中评估药物处置.

主要成果:

  • 在低剂量和高剂量下,卡斯波金在6小时内被广泛消除.
  • 隔离在低剂量下排泄的96%和高剂量下排泄的88.5%.
  • 增加卡斯波金剂量并没有显著减少过器封存.

结论:

  • 在STX过器中,高剂量并不能减轻卡斯波金的分离.
  • 同时使用caspofungin和多烯酸过器需要小心.
  • 可以考虑替代CRRT模式或抗真菌剂 (例如,可纳).