连接4万名英国生物银行参与者的Connectomes:一个多模式,多规模的大脑网络资源
Sina Mansour L1, Maria A Di Biase2, Robert E Smith3
1Department of Biomedical Engineering, The University of Melbourne, VIC, Australia.
NeuroImage
|October 15, 2023
概括
我们绘制了来自4万多名参与者的100多万个大脑连接体,提供了多样化的结构和功能网络数据. 这个资源使得大规模的人类连接组研究在健康和疾病.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 计算生物学 计算生物学
背景情况:
- 了解人类大脑复杂的网络架构对于神经科学研究至关重要.
- 之前的研究受到可用的大脑网络数据的规模和范围的限制.
研究的目的:
- 创建一个全面的,高质量的人类大脑连接组的资源.
- 为研究人员提供灵活的工具和数据来研究大脑结构和功能.
主要方法:
- 利用扩散核磁共振和通道图进行结构连接性估计.
- 使用休息状态的功能性MRI来推断区域功能连接.
- 处理了超过4万名英国生物库参与者的数据,产生了超过一百万个连接组.
主要成果:
- 产生了结构和功能连接体的大规模数据集,具有多个分片细分度和连接性测量.
- 开发了高效的管道,用于重建每个主题的众多连接组版本.
- 通过严格的质量控制程序,确保数据的可靠性和准确性.
结论:
- 英国生物银行连接组资源为人类大脑网络研究提供了前所未有的规模.
- 这个资源促进了对人类连接体在健康,疾病和衰老方面的新研究.
- 开放的数据和管道将加速网络神经科学领域的发现.
相关概念视频
Brain Imaging
235
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
235
Organization of the Brain
820
The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
820
Anatomy of the Brain: Major Regions
4.7K
The brain is the most complex organ in the human body. It consists of four main parts: the cerebrum, diencephalon, cerebellum, and brainstem.
The cerebrum is the largest section of the brain and divides into left and right hemispheres, separated by a deep fissure. The cerebral outer layer of grey matter — the cerebral cortex — comprises elevations called gyri and shallow groves called sulci. The inner portion of white matter includes long nerve fibers known as axons, which connect...
The cerebrum is the largest section of the brain and divides into left and right hemispheres, separated by a deep fissure. The cerebral outer layer of grey matter — the cerebral cortex — comprises elevations called gyri and shallow groves called sulci. The inner portion of white matter includes long nerve fibers known as axons, which connect...
4.7K


