围神经网络异常导致衰老和神经疾病的机制
Yixiao Dong1, Kunkun Zhao1, Xuemei Qin1
1Modern Research Center for Traditional Chinese Medicine, the Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan, China; Key Laboratory of Effective Substances Research and Utilization in TCM of Shanxi Province, Taiyuan, China.
Ageing research reviews
|October 15, 2023
概括
周神经网络 (PNN) 对大脑功能至关重要,随着年龄和疾病而发生变化. 了解PNN调节可能会揭示神经系统疾病的治疗方法.
科学领域:
- 神经科学是一个神经科学.
- 细胞外矩阵生物学 细胞外矩阵生物学
- 神经退行性疾病 神经退行性疾病
背景情况:
- 周神经网络 (PNN) 是中枢神经系统中复杂的细胞外矩阵,主要与表达帕尔瓦胺 (PV) 的GABAergic内部神经元相关.
- PNN对于突触功能,学习,记忆和调节氧化应激和炎症至关重要.
- PNN结构和功能的关键调节者包括蛋白质氨酸酸酶σ (PTPσ),正极管母体盒2 (Otx2) 和erb-b2受体氨酸激酶4 (ErbB4).
研究的目的:
- 审查调节PNN形成和维护的机制.
- 总结PNN异常在衰老和神经疾病中的作用.
- 探索针对与年龄相关的神经疾病的PNN的潜在治疗策略.
主要方法:
- 对PNN结构,功能,调节和疾病相关性研究的文献综述.
- 分析了由各种因素导致PNN调节的分子机制.
- 综合证据,将PNN变化与衰老和神经系统疾病联系起来.
主要成果:
- PNN由特定的分子因素动态调节,并受到糖氨基甘油 (GAG) 硫化的影响.
- 在老化和神经疾病中观察到异常PNN变化,如阿尔茨海默病,帕金森病,精神分裂症,自闭症和多发性硬化症.
- PNN与衰老/年龄相关疾病之间的关系是一个未被充分探索但至关重要的领域.
结论:
- PNN在维持神经电路的稳定性和功能方面发挥着重要作用.
- PNN的失调有助于衰老和各种神经疾病的病理生理学.
- 准PNN是开发神经系统疾病新型治疗干预的有希望的途径.
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