基于carboxymethyl agarose和N-isopropylacrylamide的温度敏感多功能智能响应水凝:可控制药物释放和加速伤口愈合
Yu Cai1, Liying Xin2, Peng Sun2
1Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, 977 Gongyuan Road, Yanji 133002, China.
Carbohydrate polymers
|October 15, 2023
概括
装有利多卡因的新型温度敏感水凝贴片 (CPAG) 加快了伤口愈合. 这种智能包裹可以减少疼痛和出血,同时通过控制药物释放和多功能治疗效果促进更快的伤口关闭.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 伤口护理 伤口护理
背景情况:
- 伤口愈合通常因创伤后疼痛而复杂,这是当前伤口带中经常被忽视的一个因素.
- 现有的治疗方法缺乏综合的方法来管理疼痛,同时促进有效的组织修复.
研究的目的:
- 开发一种多功能,对温度敏感的智能水凝贴片 (CPAG),用于增强伤口愈合.
- 将利多卡因用于止痛和酸用于抗氧化和静血性质.
- 研究水凝对温度的反应行为及其对伤口愈合和药物输送的影响.
主要方法:
- 通过将N- isopropylacrylamide和acrylamide植入改性碳素甲基亚加,封装酸和利多卡因而合成的CPAG水凝.
- 使用FTIR,1HNMR,SEM和风湿学进行表征,以评估结构和温度灵敏度.
- 在体外释放药物的研究,MTT测定,H&E染色,以及体内疼痛行为和伤口愈合评估.
主要成果:
- 在30°C时,CPAG表现出对温度敏感的收缩,可能加速伤口愈合.
- 观察到受控的利多卡因释放,受聚合物-水相互作用的影响.
- LID@CPAG表现出显著的疼痛抑制 (67.83%),减少出血 (54.3%的减少),以及高的伤口愈合率 (97%).
- 通过MTT,H&E染色和刺激试验证实了生物安全性.
结论:
- 开发的CPAG水凝作为一个多功能带,用于伤口愈合.
- 它有效控制利多卡因的释放,提供止痛,并表现出抗氧化和静血性质.
- CPAG显示出加速伤口关闭和改善治疗结果的巨大潜力.
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