严重的疾病活动可能会使患者易于患上与性结肠炎相关的术后双炎
Akira Sonoda1, Naoki Yoshimura1, Minako Sako1
1Center for Inflammatory Bowel Disease, Tokyo Yamate Medical Center, Japan Community Healthcare Organization, Japan.
Internal medicine (Tokyo, Japan)
|October 15, 2023
概括
由于严重的性结肠炎 (UC) 的结肠切除术可能引发十二指肠炎. 患有较高疾病活性的患者和在手术前接受氨酸抑制剂或抗瘤缩因子 (TNF) -α剂的患者更容易患上这种并发症.
科学领域:
- 胃肠病学 胃肠病学
- 炎症性肠道疾病是什么
- 临床医学 临床医学
背景情况:
- 在性结肠炎 (UC) 患者中观察到与胃病不同的十二指肠粘膜扩散性炎症.
- 与UC相关的十二指肠炎的确切原因尚不清楚,但对于耐火性UC的集体切除似乎是一个触发因素.
研究的目的:
- 在患有医疗耐药性性结肠炎的患者中进行切除术后的UC相关十二指肠炎的特征.
- 为了确定与UC. colectomy后十二指肠炎的发展相关的临床因素.
主要方法:
- 一项回顾性病例对照研究分析了45名患有UC的患者,这些患者接受了小肠切除术和食道胃管腺镜检查.
- 与UC相关的十二指肠炎是基于临床,内镜和组织学发现来诊断的.
- 十二指甲炎和非十二指甲炎组之间的临床数据,疾病严重程度 (C-反应蛋白,部分梅奥得分) 和药物进行了比较.
主要成果:
- 在45名患者中发现了10例UC相关的十二指肠炎.
- 双关节炎患者在切除前的疾病严重程度 (C-反应蛋白,部分梅奥得分) 显著更高.
- 100%的十二指甲状腺炎患者接受了救援疗法 (氨酸抑制剂或抗TNF-α剂),而非十二指甲状腺炎患者的比例为65.7%.
结论:
- 在性结肠炎 (UC) 中疾病活性较高的患者有增加患结肠切除术后十二指肠炎的风险.
- 使用救援疗法,包括氨酸抑制剂和抗瘤缩因子 (TNF) -α剂,与切除术后UC相关的十二指肠炎的发病率较高有关.
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