自身免疫性肺气膜蛋白质症,由髓质疏松症综合征复杂化
Minako Shimaya1, Yuji Inagaki1, Toru Arai2
1Department of Internal Medicine, NHO Kinki Chuo Chest Medical Center, Japan.
Internal medicine (Tokyo, Japan)
|October 15, 2023
概括
自身免疫性肺膜蛋白酶 (APAP) 是由抗粒细胞巨细胞殖民地刺激因子 (GM-CSF) 抗体引起的. 测量这些抗体对于诊断PAP至关重要,即使是同时发生的骨髓质疏松症候群 (MDS).
科学领域:
- 肺部医学 肺部医学
- 免疫学 免疫学 免疫学
- 血液学 血液学 血液学
背景情况:
- 肺膜蛋白酶 (PAP) 涉及到肺空气空间中异常表面活性剂的积累.
- 自身免疫性PAP (APAP) 源于因抗粒细胞-巨细胞殖民地刺激因子 (GM-CSF) 自体而导致的巨细胞功能障碍.
- 二次性PAP (SPAP) 与其他疾病,如骨髓质疏松综合征 (MDS) 有关,并且缺乏特定的抗GM-CSF自身抗体.
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