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免疫抑制性瘤微环境和子宫纤维瘤:在原蛋白合成中的作用

Eslam E Saad¹, Rachel Michel², Mostafa A Borahay¹

¹Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Cytokine & growth factor reviews

|October 15, 2023

概括

子宫纤维瘤 (UF) 与瘤免疫微环境的变化有关,促进细胞外基质 (ECM) 沉积. 针对这种免疫抑制环境可能为UF提供新的治疗策略.

科学领域:

妇科瘤学妇科瘤学
免疫学免疫学免疫学
病理学病理学病理学

背景情况:

子宫纤维瘤 (UF) 或乳腺瘤是影响全球妇女健康的常见子宫瘤.
危险因素包括种族,年龄,荷尔蒙影响,肥胖和生活方式.
UF的发病包括细胞增殖,血管生成和细胞外基质 (ECM) 积累.

研究的目的:

审查瘤免疫微环境在调解子宫纤维瘤中ECM沉积中的作用.
突出免疫抑制细胞及其分泌的因素,参与UF病原发生.
提出针对UF免疫微环境的新型治疗策略.

主要方法:

文献综述侧重于免疫微环境在UF中的作用.
对免疫抑制细胞 (M2巨细胞,MDSCs,Th17细胞) 和它们的分泌物 (细胞因子,生长因子) 的分析.
检查了在UF中免疫两极化和ECM积累之间的联系.

主要成果:

瘤免疫微环境,特别是其对免疫抑制表型的两极化,是UF中ECM沉积的关键调解者.
免疫抑制细胞,如M2巨细胞,MDSC和Th17细胞,以及它们分泌的因子 (例如IL-4,IL-10,TGF-β1),有助于ECM积累.
改变的免疫微环境促进了UF生长和ECM沉积,这是UF病变的标志.

结论:

UF免疫微环境是ECM沉积和瘤进展的关键因素.
准UF免疫微环境的免疫抑制成分是一个有前途的新疗法.
对UF免疫调节的进一步研究是有必要的,以开发超越传统荷尔蒙疗法的替代治疗方法.

关键词:

这是一个ECM,ECM是ECM.M2 大细胞在MDSCs中.TH1717 的时间.子宫纤维瘤在子宫纤维瘤.

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