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Updated: Jul 13, 2025

Chemical Triphosphorylation of Oligonucleotides
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具有线性二硫化物促进性的原药类型三聚原核酸对减少环境的反应

Norihito Sugimoto1, Junsuke Hayashi1, Ryohei Funaki1

  • 1Department of Bioorganic Chemistry, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University, 4-20-1 Nasahara, Takatsuki, Osaka, 569-1094, Japan.

Chembiochem : a European journal of chemical biology
|October 15, 2023
PubMed
概括

新的线性二硫酸三寡核酸 (PTE ONs) 显示了转化和细胞吸收的改善. 这些修饰的反感性寡核酸 (AONs) 显示出增强的核酶抗性和治疗应用的潜力.

关键词:
反感的寡核化物.线性二硫化物促进物质.三的修饰方法是三.药物前体是药物前体.减少活性激活的减少活性激活

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