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The Tail Suspension Test
Published on: January 28, 2012
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关于相关体重增加的争议:对现实世界药物安全数据的病例对照研究
Waldemar Greil1,2, Mateo de Bardeci3,4, Bruno Müller-Oerlinghausen5,6,7
1Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Nussbaumstr. 7, 80331, Munich, Germany. waldemar.greil@med.uni-muenchen.de.
International journal of bipolar disorders
|October 15, 2023
概括
与lamotrigine相比,治疗显示出更多的严重体重增加报告,但低于 olanzapine,quetiapine 和 valproate. 对服用这些情绪稳定剂的患者来说,监测体重增加至关重要.
科学领域:
- 精神病学是一个精神病学.
- 药物监督 药物监督 药物监督
- 代谢不良反应药物反应
背景情况:
- 长期治疗对体重增加的影响仍在争论中.
- 关于诱导的体重增加,存在相互矛盾的证据.
- 拉莫特里金被认为是代谢中性的.
研究的目的:
- 评估与和其他情绪稳定剂相关的体重增加报告.
- 为了将这些药物与lamotrigine进行比较,对代谢药物不良反应 (ADRs) 的控制.
主要方法:
- 使用AMSP项目数据库进行病例/非病例药监研究.
- 不成比例分析计算体重增加 (>10%的体重) 报告几率比率 (ROR).
- 与拉莫特里金相比,阿里皮普拉,卡巴马泽,,奥兰扎宾,奎蒂亚平,Risperidone和瓦尔酸的比较.
主要成果:
- 与lamotrigine相比,在体重增加方面显示了2.1的非显著ROR.
- 奥兰扎 (ROR: 11.5),奎蒂亚平 (ROR: 3.4) 和氨酸 (ROR: 2.4) 在体重增加方面具有统计学上显著的较高ROR.
- 在非老年患者中,严重的体重增加更为普遍,在这个群体中,和非使用者的ROR更高.
结论:
- 与比拉莫特里金更严重的体重增加报告有关,尽管在统计学上并不显著.
- 使用导致的严重体重增加报告少于 olanzapine,quetiapine 和 valproate.
- 持续监测体重增加和代谢参数对于服用和替代性情绪稳定剂的患者至关重要.
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