持续和重复的代谢测量与心胸外科手术后和重症监护患者之间的比较
Koichiro Shinozaki1,2,3,4, Pey-Jen Yu5, Qiuping Zhou6
1The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA. shino@gk9.so-net.ne.jp.
BMC pulmonary medicine
|October 15, 2023
概括
一个新的系统准确地测量了新陈代谢指标,如氧气消耗 (VO2) 和二氧化碳产生 (VCO2). 临界护理患者的代谢变化比心胸外科手术后的患者少,这表明临界病患者的系统差异.
科学领域:
- 心胸外科手术和重症监护医学.
- 呼吸系统生理学和代谢监测.
背景情况:
- 精确测量代谢指标,如氧气消耗 (VO2),二氧化碳生成 (VCO2) 和呼吸系数 (RQ),对于患者管理至关重要.
- 道格拉斯袋 (DB) 技术是黄金标准,但具有侵入性,不适合持续监测.
研究的目的:
- 开发和验证一种用于连续和重复测量VO2,VCO2和RQ的新系统.
- 为了比较心胸外科手术后患者和重症监护患者之间的代谢指标值.
主要方法:
- 一项前性观察性研究在四级护理教学医院进行.
- 18岁或以上需要机械通风的患者被纳入.
- 针对道格拉斯袋技术进行验证的新系统被用于连续的代谢测量.
主要成果:
- 该研究包括4名手术后和6名重症监护患者;3名重症监护患者没有存活.
- 连续测量长达12小时15分钟,进行50次重复周期.
- 与重症监护患者相比,手术后的患者表现出更多可变的VO2值. 较高的SOFA分数与非生存相关,与RQ相关负.
结论:
- 成功开发了一种用于连续测量VO2,VCO2和RQ的准确系统.
- 与心胸外科手术后的患者相比,重症监护患者的代谢变化 (VO2,VCO2) 随着时间的推移较小.
- 变化的代谢指标值可能意味着重症患者的系统差异.
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