莱普Rs7799039多态性与2型糖尿病有关 埃及患者
Amal Ahmed Mohamed1, Dina M Abo-Elmatty2, Alaa S Wahba2
1Department of Biochemistry, National Hepatology and Molecular Biology & Tropical Medicine Research Institute, Cairo, Egypt.
Archives of physiology and biochemistry
|October 16, 2023
概括
较低的血清瘦素 (LEP) 水平和LEP rs7799039遗传变异与2型糖尿病 (T2DM) 的风险增加有关. 这表明LEP在埃及患者的T2DM病变发生过程中发挥了作用.
科学领域:
- 遗传学 是一个遗传学.
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
背景情况:
- 素 (LEP) 是一种调节新陈代谢的激素,其基因 (LEP) 和受体 (LEPR) 变体与2型糖尿病 (T2DM) 和肥胖症有关.
- 影响LEP的遗传因素可能会导致T2DM的发展.
研究的目的:
- 在埃及患者中调查血清LEP水平,LEP基因多态 (rs7799039,2548 G/A) 和T2DM之间的关联.
主要方法:
- 一项病例控制研究包括100名T2DM患者和105名健康对照.
- 使用ELISA测量血清LEP水平,并使用聚合酶链反应TaqMan技术对LEP基因变异进行基因定型.
主要成果:
- 与对照组相比,T2DM患者表现出改变的代谢标志物 (例如,HbA1c,葡萄糖,脂质的升高) 和显著降低的血清LEP水平.
- 在T2DM患者中,LEP rs7799039多态性,特别是A等位基因和AA/GA基因型,更频繁,并且与糖尿病风险增加和血糖控制较差相关.
- 血清LEP水平与T2DM状态相反,与rs7799039多态相相关.
结论:
- 在埃及人群中,LEP rs7799039基因变异和改变的血清LEP水平与T2DM易感性有显著联系.
- LEP水平和rs7799039多态可能是T2DM病变发生的重要因素.
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