在患有肥胖的人群中,较低的肌肉蛋白质合成与较低的肌肉IGF1拼接变体表达一致
Eduardo D S Freitas1, Katon A Kras1, Lori R Roust2
1School of Life Sciences, Arizona State University, Tempe, Arizona, USA.
Obesity (Silver Spring, Md.)
|October 16, 2023
概括
肥胖患者肌肉蛋白质合成较低,原因是胰岛素类生长因子1 (IGF-1) 基因表达减少. 这项研究将肥胖与降低IGF-1和IGF-1受体蛋白水平联系起来,影响肌肉健康.
科学领域:
- 代谢研究的研究.
- 肌肉生理学 肌肉生理学
- 内分泌学 在内分泌学.
背景情况:
- 肥胖与代谢功能障碍和蛋白质代谢改变有关.
- 胰岛素样生长因子1 (IGF-1) 在肌肉蛋白质合成和生长中起着至关重要的作用.
- 以前的研究表明,肥胖和肌肉蛋白质合成受损之间存在联系.
研究的目的:
- 调查假设,胰岛素样生长因子1 (IGF-1) 蛋白质和mRNA拼接变体的骨肌肉表达在肥胖的人群中较低.
- 为了比较肥胖和没有肥胖的个体之间的混合肌肉蛋白分数合成率 (MMP-FSR).
- 为了检查肥胖,MMP-FSR和IGF-1在骨肌肉中的信号通路之间的关系.
主要方法:
- 该研究包括肥胖 (OB) 和没有肥胖 (W-OB) 的参与者.
- 混合肌肉蛋白分数合成率 (MMP-FSR) 和线粒体蛋白FSR是在禁食状态下测量的.
- 在骨肌组织中分析了IGF-1蛋白,IGF-1受体蛋白和IGF1mRNA拼接变体 (Eb和Ec) 的表达水平.
主要成果:
- 与那些没有肥胖的人相比,肥胖的参与者表现出明显较低的MMP-FSR.
- 肥胖个体的骨肌肉显示IGF-1蛋白和IGF-1受体蛋白的表达减少.
- 在肥胖组中,IGF1拼接变体Eb和Ec的mRNA表达也明显较低.
结论:
- 肥胖个体的骨肌肉中较低的蛋白质合成与IGF-1和IGF-1受体蛋白的表达减少有关.
- 减少肌肉IGF1基因表达可能导致肥胖症中观察到的肌肉蛋白质合成受损.
- 这些发现凸显了IGF-1途径在与肥胖相关的肌肉相关代谢变化的作用.
相关概念视频
Overview of Protein Metabolism
1.3K
Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
1.3K
Formation of Muscle Fibers from Myoblasts
4.9K
De novo myogenesis, or the formation of muscle fibers, begins during the early embryonic stages. The skeletal muscle is formed from somites– blocks of embryonic cell layers. The somites are further divided into dermatomes, myotomes, sclerotomes, and syndetomes. Among these, the myotomes give rise to muscle fibers.
Muscle progenitor cells (MPCs) are formed from the myotomes. MPCs express genes that encode the transcription factors Pax3 and Pax7. Along with Pax 3/7, other transcription...
Muscle progenitor cells (MPCs) are formed from the myotomes. MPCs express genes that encode the transcription factors Pax3 and Pax7. Along with Pax 3/7, other transcription...
4.9K
RNA Splicing
56.4K
Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
56.4K


