用于剂量控制和持续药物输送的软注射
Mossab K Alsaedi1,2, Omar Lone1,3, Hojatollah Rezaei Nejad1,4,5
1Nano Lab, Advanced Technology Laboratory, Tufts University, Medford, MA, 02155, USA.
Macromolecular bioscience
|October 16, 2023
概括
新的携带药物的可以提供无痛,局部和持续的皮肤传递,持续数周. 这种创新方法克服了注射和微针的局限性,以有效的药物管理.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 药物输送系统 药物输送系统
背景情况:
- 通过皮肤递送药物绕过了口服和皮下注射方法的局限性.
- 微针可以提供无痛的分娩,但药物容量和实用性有限.
- 现有的方法面临的挑战是疼痛,剂量,吸收和保留.
研究的目的:
- 开发和评估软注射,以无痛,局部和持续的通过皮肤递送药物.
- 为了证明使用作为长期药物释放的微流体通道的可行性.
- 为了比较基于接的分娩与传统方法的疗效.
主要方法:
- 制造用于皮肤植入的携带药物的可注射.
- 使用作为毛细血管微流体通道,连接到可穿戴储存器.
- 量化药物递送速度和持续时间使用5-甲和罗达胺B模型.
主要成果:
- 一个60厘米的 suture 提供0.43毫克的5-fluorouracil 在15分钟内.
- 持续提供罗达胺B超过8周以0.0195毫升/小时的速度.
- 已证明适用于所有皮肤类型,并在分娩期间有效保留.
结论:
- 软注射 sutures 代表一个有前途的平台,长期,持续的透皮药物输送.
- 这项技术比皮下注射,口服和微针在局部治疗中具有优势.
- 提供了一种多功能和有效的解决方案,可以在较长时间内提供不同量的药物.
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