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关于强制性操纵研究机制缺陷的国际共识:名义组技术的发现
Damian L Keter1,2, Jennifer A Bent3, Joel E Bialosky4,5
1Physical Medine and Rehabilitation Service, Department of Veterans Affairs Medical Center, Cleveland, OH, USA.
The Journal of manual & manipulative therapy
|October 16, 2023
概括
基于武力的操纵 (FBM) 提供疼痛缓解,但其潜在机制尚未研究. 这项研究发现了FBM研究中的关键知识缺口,强调了需要转化和个性化疼痛管理方法的需要.
科学领域:
- 疼痛研究 疼痛研究
- 手动治疗机制手动治疗机制
- 临床镇痛药 临床镇痛药
背景情况:
- 基于武力的操纵 (FBM) 包括按摩和动员等技术,已知可以改善疼痛结果.
- 这些手动干预措施导致疼痛缓解的确切机制仍未得到充分研究.
- 提出的机制包括神经学,神经免疫学,生物力学和情境因素,但它们与临床疼痛的联系尚未得到充分证实.
研究的目的:
- 确定目前基于机制的强迫操纵 (FBM) 机制研究中的缺口.
- 了解复杂的多系统对FBM的反应.
- 为了指导未来的研究,转化和个性化疼痛管理.
主要方法:
- 采用了一种国际化的多学科名义组技术 (NGT).
- 研究人员在八个领域的FBM机制研究中确定和分类了拟议的漏洞.
- 在37个确定的差距上达成共识.
主要成果:
- 23个差距达到了共识,突出了FBM多系统响应的复杂性.
- 与上下文因素和机制转化为临床结果相关的差距得到了强有力的支持.
- 生物机械领域对已识别的差距的总体支持率较低.
结论:
- 在了解FBM的止痛机制方面存在重大差距,特别是关于生物力学方面的差距.
- 将FBM机制与临床结果联系起来的翻译性研究至关重要.
- 调查FBM在疼痛表型上的差异性影响对于精确的疼痛管理至关重要.
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