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对阿尔茨海默氏症的远程辅导多模式生活方式干预改善了功能和认知结果
Jared C Roach1, Molly K Rapozo2, Junko Hara3
1Institute for Systems Biology, Seattle, WA, USA.
Journal of Alzheimer's disease : JAD
|October 16, 2023
概括
一个远程指导的多式生活方式干预显著改善了早期阿尔茨海默病和相关痴呆症 (ADRD) 的认知功能. 这种方法为管理认知衰退的标准护理提供了一个有希望的替代方案.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 阿尔茨海默病和相关痴呆症 (ADRD) 需要除了药物治疗之外的综合管理.
- 改变生活方式,包括饮食,认知训练和运动,对于ADRD的预防和治疗至关重要.
- 个性化,多式疗法对于有效管理阿尔茨海默病 (AD) 是必不可少的.
研究的目的:
- 测试假设,远程指导的多模式生活方式干预可以改善早期AD的认知功能.
- 评估与标准护理相比,阿尔茨海默氏症认知辅导 (COCOA) 试验干预的疗效.
主要方法:
- 一项前性随机对照试验,涉及早期AD的参与者.
- 两个分支:标准护理 (控制) 和标准护理加上对生活方式干预 (干预) 的电话个性化指导.
- 主要结果:两年内记忆性能指数 (MPI) 的变化;次要结果:功能评估分期测试.
主要成果:
- 与对照组 (p=0.016) 相比,干预组在两年内显著改善了2.1个MPI点.
- 干预组中没有报告任何重大不良事件或副作用.
- 广泛的数据 (心理测量,临床,生活方式,基因组,蛋白质组,代谢组,微生物组) 被动态收集.
结论:
- 多式生活方式干预措施在改善早期ADRD认知衰退方面是有效的.
- 远程辅导在早期ADRD管理方面表现出有效性,特别是在COVID大流行等公共卫生危机期间具有相关性.
- 饮食改变和运动可能是这些多式联络干预措施的关键有益成分.
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