用加速器测量久坐行为模式,脑结构和痴呆症免费老年人的认知功能:基于人口的研究
Xiaolei Han1,2, Lin Song1,2, Yuanjing Li3
1Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Journal of Alzheimer's disease : JAD
|October 16, 2023
概括
老年人长时间的久坐时间与较差的认知功能有关. 通过轻度活动来打破久坐期可能会改善记忆力和语言流性,而大脑结构起着调解作用.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 久坐不动行为是认知障碍的一个已知的危险因素.
- 连接久坐行为和认知衰退的潜在神经病理机制尚未得到充分理解.
研究的目的:
- 检查老年人的久坐行为模式与大脑结构和认知之间的关系.
- 探索潜在的调解机制,包括大脑结构标记.
主要方法:
- 一项针对2019名没有痴呆症的老年人 (≥60岁) 的社区研究.
- 通过加速度计评估静坐行为;通过神经心理测试评估认知功能.
- 在一个子样本 (n=1,009) 中分析的大脑MRI扫描,使用一般线性,同时置换和调解模型.
主要成果:
- 较长的久坐时间与较低的全球认知能力,语言流性和记忆力相关.
- 总体较长的静坐时间与较差的认知能力只与那些每天静坐时间超过10小时的人有关.
- 通过轻微的体力活动中断久坐的时间改善了口语流性和记忆力.
- 结构性大脑标志物部分调解了久坐时间和认知功能之间的关联.
结论:
- 长时间,不间断的静坐时间与老年人的认知功能下降有关.
- 结构性大脑变化可能部分解释了久坐不动行为如何影响认知.
- 减少长时间久坐的策略和纳入轻度活动对于衰老中的认知健康至关重要.
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