多站点跨站点互评测器和测试复试可靠性和MarkVCID白物质超强度增长和回归协议的构建有效性
Ahmed A Bahrani1,2, Erin L Abner2,3, Charles S DeCarli4
1Department of Neurology, University of Kentucky, College of Medicine, Lexington, KY, USA.
Journal of Alzheimer's disease : JAD
|October 16, 2023
概括
MarkVCID协议可靠地测量了一年内白质超强度 (WMH) 的变化. 这种神经成像生物标志物对针对血管认知障碍和痴呆症 (VCID) 的临床试验充满希望.
科学领域:
- 神经学 神经学
- 神经成像是一种神经成像.
- 生物标志物开发 生物标志物开发
背景情况:
- 在血管认知障碍和痴呆症 (VCID) 中,白质过强度 (WMH) 可以随着时间的推移而变化.
- 量化WMH变化对于开发针对VCID和阿尔茨海默病的有效临床试验至关重要.
研究的目的:
- 评估MarkVCID协议用于测量白质超强度 (WMH) 增长和回归的可靠性.
- 评估该协议作为神经退行性疾病临床试验中的生物标记物的实用性.
主要方法:
- 马克VCID联盟对WMH增长和回归协议进行了多站点可靠性测试 (测试者之间和测试重试).
- 分析了认知测试得分,以探索WMH变化的构造有效性.
主要成果:
- 较高的类内相关系数 (ICC) 值显示了对WMH生长和回归的良好测试-复试 (0.969-0.937) 和测试者间 (0.995-0.990) 的可靠性.
- 发现WMH增长和词汇列表长延迟自由回忆之间的负相关性 (p <0.028).
结论:
- MarkVCID WMH 增长/回归协议在一年时间内表现出强大的可靠性.
- 这种经过验证的方法适用于临床试验,研究VCID的疾病修饰剂,特别是影响WMH动态的疾病修饰剂.
关键词:
衰老的衰老 衰老的衰老阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.标记VCIDID 标记VCID 标记VCID 标记脑血管疾病 脑血管疾病痴呆症 痴呆症是一种痴呆症.在纵向的长度上.小血管缺血病是一种小血管缺血病.白质超强度是白质的超强度.更多相关视频
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