2023年中国脂质管理指南
Jian-Jun Li1, Shui-Ping Zhao2, Dong Zhao3
1National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Journal of geriatric cardiology : JGC
|October 16, 2023
概括
新的中国指南强调低密度脂蛋白胆固醇 (LDL-C) 管理,以预防动脉样硬化心血管疾病 (ASCVD). 他们建议作为初始治疗的他类药物,以及高风险个体的其他疗法,指导所有年龄组的临床实践.
科学领域:
- 心脏病学 心脏病学
- 公共卫生 公共卫生
- 内分泌学 在内分泌学.
背景情况:
- 动脉样性心血管疾病 (ASCVD) 是中国的主要死亡原因.
- 低密度脂蛋白胆固醇 (LDL-C) 的升高是ASCVD的重要危险因素.
- 越来越多的ASCVD负担需要更新的脂质管理策略.
研究的目的:
- 修订和调整现有的失脂症指南,并将其纳入新的"中国脂质管理指南".
- 根据全球研究的突破,为脂质控制提供最新的建议.
- 为各种人群建立风险分层的目标LDL-C水平.
主要方法:
- 一个专家委员会调整了"预防和治疗脱脂症的指南".
- 新的指南利用心血管疾病 (CVD) 风险分层来确定目标LDL-C值.
- 建议包括改变生活方式,中度强度的他类药物治疗,以及其他药物,如PCSK9抑制剂.
主要成果:
- LDL-C仍然是脂质控制的主要目标.
- 最初的治疗包括中度强度的他类药物和生活方式的改变.
- 建议使用胆固醇吸收抑制剂和PCSK9抑制剂作为二线治疗.
- 为所有年龄组的脂质管理提供了指导,从儿童到老年人.
结论:
- 新的指导方针旨在全面改善中国的脂质管理.
- 它们为临床实践提供了一个框架,以加强ASCVD预防和治疗.
- 风险分层对于定制LDL-C目标和治疗策略至关重要.
相关概念视频
Lipids: Dietary Sources and Requirements
769
Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
769
Atherosclerosis III: Management
11
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
11
Blood Studies for Cardiovascular System III: Serum Lipid Profile
168
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
168
Coronary Artery Disease IV: Preventive Measures
23
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
23
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
678
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
678
Angina IV: Management
10
IntroductionThe management of angina requires a comprehensive approach that includes pharmacological therapies, medical procedures, and lifestyle modifications.Pharmacological TherapiesAntiplatelet agents, such as aspirin, clopidogrel, prasugrel, and ticagrelor, play a pivotal role in preventing thrombus formation in patients with angina. These medications inhibit platelet aggregation and reduce the likelihood of myocardial infarction and other cardiovascular events.Anticoagulants, including...
10


