通过辅助生殖技术怀孕的后代与单胞胎双胞胎相关的危险因素
Na Chen1,2,3,4,5,6,7, Jingyu Li1,2,3,4,5,6,7, Yexing Li1,2,3,4,5,6,7
1Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Human reproduction open
|October 16, 2023
概括
辅助生殖技术 (ART) 增加了单胞胎双胞胎 (MZ) 的风险. 父母年龄,胚胎移植类型 (新鲜或冷) 和胚胎细胞质等级影响ART后代的MZ结合.
科学领域:
- 生殖医学 生殖医学
- 遗传学 遗传学 是一个
- 胚胎学 胚胎学
背景情况:
- 辅助生殖技术 (ART) 与单胞胎 (MZ) 双胞胎的发病率较高有关,这可能是由于不育人口中的因素.
- 了解这些因素对于管理ART结果和优化患者护理至关重要.
研究的目的:
- 为了调查在ART后单胞胎 (MZ) 双胞胎的发病率.
- 为了确定与MZ双胞胎结合相关的特定风险因素,在ART怀孕后代.
主要方法:
- 一项队列研究涉及255个单卵双胞胎和1020个匹配的单卵双胞胎,所有这些都是通过单胚胎移植 (SET) 怀孕的.
- 分析的重点是父母的特征,性子/胚胎操纵和胚胎发育因素.
- 后勤回归被用来识别显著的风险因素.
主要成果:
- 在SET之后,MZ双胞胎的发病率为1.638%.
- 冷胚胎移植 (FET) 和更高的父亲年龄与减少MZ结合的风险有关.
- 较高的母亲年龄和胚胎细胞移植与风险增加有关.
- 特定的胚胎囊等级 (例如,C等级TE) 显示对MZ结对产生保护作用.
结论:
- 父母的年龄,胚胎移植方法 (新鲜或冷) 和母细胞质量是影响MZ双胞胎在ART中的重要因素.
- 结果为高风险ART人群的临床干预提供了洞察力.
- 限制包括通过SET后的出生结果和同质的父母特征来定义MZ双胞胎.
关键词:
艺术 艺术 艺术 艺术美国国务院调查局 (ICSI)在这个过程中,IVF IVF.胚胎细胞囊中的胚胎囊.不育人口的特征 不育人口的特征.布拉斯托囊细胞的分类方法在冷胚胎移植 (FET) 中进行胚胎移植.玩偶或胚胎操纵的操作.双胞胎是单胞胎 (MZ) 双胞胎.单个胚胎转移 (SET) 是指一个胚胎转移.更多相关视频
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