整体肥胖,而不是腹部肥胖在个人级别数据中与阻塞性睡眠呼吸暂停有因果关系
1Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Sleep Disordered Breathing, Otorhinolaryngology Institute of Shanghai JiaoTong University, Shanghai, People's Republic of China.
Nature and science of sleep
|October 16, 2023
概括
总体而言,肥胖,特别是在男性中,因果上增加了阻塞性睡眠呼吸暂停 (OSA) 和相关呼吸问题的风险. 然而,腹部肥胖在本研究中没有显示出这种因果关系.
科学领域:
- 医学研究 医学研究
- 遗传学 是一个遗传学.
- 睡眠医学 睡眠医学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 和肥胖是全球普遍存在的健康问题.
- 肥胖是已知的OSA风险因素,但因果关系需要进一步调查.
研究的目的:
- 调查整体肥胖和腹部肥胖与OSA之间的因果关系.
- 分析肥胖指标和定量OSA特征之间的因果关系.
主要方法:
- 一项病例控制研究涉及7134名参与者 (4335名OSA,2799名对照).
- 孟德尔随机化 (MR) 分析使用BMI和WHR的遗传风险得分作为仪器变量.
- 对遗传分数和OSA之间的因果关系的分析,包括呼吸暂停-呼吸暂停指数 (AHI),氧气不和指数 (ODI) 和平均呼吸暂停指数 (MAI).
主要成果:
- 观察分析显示,肥胖和OSA之间存在很强的相关性 (β=0.055,P=3.7×10−5).
- 核磁共振分析表明,BMI增加1个标准偏差与男性增加的OSA风险 (OR:2.21) 和更高的AHI,ODI和MAI有关.
- 在两性中,腰比 (WHR) 与OSA风险或定量特征之间没有发现因果关系.
结论:
- 整体肥胖表明与OSA及其定量特征的因果关系,特别是在男性中.
- 在本研究中,腹部肥胖 (用WHR测量) 似乎与OSA没有因果关系.
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