引起下呼吸道感染的病原体的分布模式基于基因组下一代测序
Shukun Chai1, Chuan Wang1, Yi Liu1
1Department of Respiratory Medicine, Shijiazhuang People's Hospital, Shijiazhuang, Hebei, 050051, People's Republic of China.
Infection and drug resistance
|October 16, 2023
概括
下呼吸道感染 (LRTI) 涉及频繁的联合感染与各种病原体显示季节性模式. 了解这些模式有助于早期诊断和治疗LRTI.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 基因组学就是基因组学.
背景情况:
- 下呼吸道感染 (LRTI) 是一个重要的全球健康问题,导致大量的发病率和死亡率.
- 准确识别致病原体对于有效的LRTI管理至关重要.
研究的目的:
- 调查导致LRTI的病原体的分布模式.
- 为了比较常规的微生物学测试 (CMT) 与元基因下一代测序 (mNGS) 进行病原体检测.
- 分析LRTI患者的季节性流行和同时感染模式.
主要方法:
- 对160名怀疑LRTI的患者进行了回顾性队列研究.
- 分析各种临床样本,包括支气管支气管洗液 (BALF),血液,组织,和.
- 结合CMT和mNGS进行全面的病原体识别.
主要成果:
- 分析了137名患者和156个样本,确定了流行病原体,如*Pseudomonas aeruginosa*,*Klebsiella pneumoniae*,*Candida*和人类疹病毒.
- 观察到关键细菌和病毒的流行季节性变化.
- 记录有高的同时感染率,包括细菌-病毒和细菌-真菌-病毒混合感染,特别是在老年人中.
结论:
- 在LRTI患者中,共感染很常见,病原体表现出明显的季节性分布.
- 这项研究强调了了解病原体动态对于及时的病因诊断的重要性.
- 将mNGS与CMT集成为全面的LRTI病原体分析提供了一个强大的方法.
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