长期暴露于空气污染和普遍存在的非酒精性脂肪肝疾病
Clara Matthiessen1, Lina Glaubitz1, Sarah Lucht1,2
1Institute of Occupational, Social, and Environmental Medicine, Centre for Health and Society, Medical Faculty, Heinrich-Heine University Düsseldorf, Germany.
Environmental epidemiology (Philadelphia, Pa.)
|October 16, 2023
概括
长期暴露于空气污染与非酒精性脂肪肝疾病 (NAFLD) 的更高患病率有关. 这项研究发现空气污染物和NAFLD之间存在积极联系,突出了对肝脏健康的潜在环境风险因素.
科学领域:
- 环境健康 环境健康
- 肝病学 肝病学是一种肝病学.
- 流行病学 流行病学
背景情况:
- 非酒精性脂肪性肝病 (NAFLD) 涉及肝脏中的脂肪积累,没有二次原因.
- 空气污染 (AP) 与代谢综合征和糖尿病有关,这些疾病与NAFLD相关.
- 很少有研究研究了AP暴露与NAFLD患病率之间的直接关系.
研究的目的:
- 检查暴露于空气污染和NAFLD患病率之间的关联.
- 为了确定像AP这样的环境因素是否会导致肝硬化.
主要方法:
- 利用了来自海因茨-尼克斯多夫-雷卡尔队列研究 (n=4,814) 的横截面数据.
- 使用两种暴露模型评估对颗粒物 (PM10,PM2.5,PM粗,PM2.5abs),二氧化和颗粒数量的暴露.
- 在4065名参与者中,使用脂肪肝指数 (FLI ≥60) 确定了NAFLD.
- 后勤回归分析估计了NAFLD的概率比率 (ORs) 对于污染物暴露的四分位数间范围,经过调整以考虑混因素.
主要成果:
- 在研究人群中,NAFLD的患病率为31.7%.
- 所有测量的空气污染物都显示出与NAFLD患病率的积极关联.
- 使用化学传输模型,PM2.5暴露的四分位数间范围增加与OR为1.11 (95%CI:1.00-1.24) 相关.
结论:
- 长期暴露于空气污染与NAFLD有积极的关联.
- 空气污染可能是NAFLD发展的重要环境风险因素.
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