在中国人口中,miR-365多态和缺血性中风之间的关联
Yin-Hua Weng1,2,3, Wen-Tao Yu3, Yan-Ping Luo3
1Department of Laboratory Medicine, The Second Affiliated Hospital of Guilin Medical University, Guilin, China.
Frontiers in neurology
|October 16, 2023
概括
在miR-365中的单核酸多态,特别是rs30230,与缺血性中风 (IS) 风险有关. 通过降低miR-365表达,rs30230 TC/TT基因型可以提供对IS的保护.
科学领域:
- 遗传学 是一个遗传学.
- 分子生物学分子生物学
- 神经学 神经学
背景情况:
- 缺血性中风 (IS) 是全球死亡率和发病率的主要原因.
- 异常的microRNA-365 (miR-365) 表达与动脉样硬化和癌症等疾病有关.
- 在miRNA基因中的单核酸多态 (SNP) 对于理解疾病易感性至关重要.
研究的目的:
- 研究miR-365单核酸多态 (SNPs) 与缺血性中风 (IS) 风险之间的关联.
- 在IS患者中探索miR-365表达水平和特定miR-365基因型之间的关系.
主要方法:
- 在215名IS患者和220名对照中使用SNP扫描对3个miR-365多态位点 (rs121224,rs30230,rs178553) 的基因型定型.
- 通过实时定量PCR对外围血液单核细胞中miR-365相对表达的量化.
- 统计分析包括调整的赔率比率 (OR) 和单元型分析.
主要成果:
- 这种miR-365 rs30230多态表现出与降低IS风险的显著关联 (例如,TC与CC:OR=0.55,P=0.022).
- 哈普洛型分析表明,C-T-G哈普洛型与IS风险降低有关 (OR=0.68,P=0.047).
- 在IS患者中,miR-365表达显著高于对照组 (P < 0.001),在rs30230TC/TT基因型中水平较低 (P < 0.001).
结论:
- 在研究的人群中,miR-365 rs30230多态性与缺血性中风易感性有关.
- rs30230 TC/TT基因型可以作为抗缺血性中风的保护因素.
- 改变的miR-365表达水平与特定的基因型和IS风险相关.
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