在患有活跃和隐藏癌症的患者中,过渡性缺血性发作
Morin Beyeler1,2, Pasquale Castigliego1, Joel Baumann1
1Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Frontiers in neurology
|October 16, 2023
概括
脑膜瘤凝血病是一种与癌症相关的疾病,可以表现为暂时性缺血性发作 (TIA). 在TIA患者中识别癌症生物标志物可能会改善结果并帮助早期发现癌症.
科学领域:
- 神经学 神经学
- 在瘤学瘤学.
- 血液学 血液学 血液学
背景情况:
- 性凝血病是已知的中风原因,与特定的癌症生物标志物有关.
- 它与暂时性缺血性发作 (TIA) 的关联以及对死亡率的影响仍然不太清楚.
研究的目的:
- 调查TIA患者癌症相关生物标志物的存在.
- 评估活跃癌症和TIA之间的关联.
- 分析TIA患者的长期死亡率,包括患有癌症和没有癌症的患者.
主要方法:
- 在中风中心对连续TIA患者 (2015-2019) 的回顾性分析.
- 多变量逻辑回归用于评估癌症和生物标志物之间的关联.
- 多变量考克斯回归分析长期死亡率.
主要成果:
- 5%的TIA患者患有活跃癌症,其中1.2%患有隐性癌症.
- 与癌症相关的TIA与男性性别,吸烟史,D-二次体升高,乳酸脱酶升高,白细胞数量降低和血红蛋白降低有关.
- 活跃癌症和隐性癌症都与TIA后的长期死亡率增加有关.
结论:
- 与癌症相关的TIA是一个重要的临床实体.
- 与癌症相关的中风相关的生物标志物也在TIA患者中观察到.
- 在TIA患者中早期发现癌症可能会改善预后,并使有针对性的治疗成为可能.
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