在低海拔地区潜在的血生物标志物用于预测急性山病
Haoran Guo1,2, Qi Wang3, Tao Li4
1Medical School of Chinese PLA, Beijing, China.
Frontiers in immunology
|October 16, 2023
概括
预测急性山病 (AMS) 是一个挑战. 这项研究确定了特定的血蛋白,包括AAT,SAP,LTF和HSP90-α,作为预测低海拔地区AMS易感性的潜在生物标志物.
科学领域:
- 生理学 生理学 生理学
- 蛋白质组学是指蛋白质组学
- 生物标志物发现发现
背景情况:
- 高海拔上升会导致生理变化,一些低地人无法适应.
- 在高度暴露之前预测急性山病 (AMS) 仍然很困难.
研究的目的:
- 为了确定血蛋白生物标志物来预测AMS易感性.
- 为了阐明与不同高度的AMS相关的差异表达蛋白 (DEPs).
主要方法:
- 从40名参与者 (发现队列) 的血样本的蛋白质组分析,按AMS严重程度分层.
- 在118名参与者队列中使用ELISA验证选定的DEP (验证队列).
- 接收器操作特征 (ROC) 分析,以评估生物标志物的预测效率.
主要成果:
- 在与免疫相关的途径,如粒细胞激活和中性粒细胞免疫,DEP被丰富.
- 在严重的AMS (sAMS) 与低海拔地区的非AMS组中AAT,SAP和LTF的升高水平显示出高预测值 (AUC=0.965).
- SAP和LTF区分了中度AMS (mAMS) 与sAMS (AUC=0.887),而HSP90-α和SAP区分了在低海拔地区的mAMS与非AMS (AUC=0.874).
结论:
- 炎症和免疫反应在AMS易感和耐药个体之间存在显著差异.
- 在低海拔地区,SAP,AAT,LTF和HSP90-α显示为AMS的预测生物标志物.
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