在SARS-CoV-2和Mycobacterium结核病之间的免疫相互作用
Petro Booysen1,2, Katalin A Wilkinson1,2,3, Dylan Sheerin4,5
1Centre for Infectious Diseases Research in Africa (CIDRI-Africa), Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Frontiers in immunology
|October 16, 2023
概括
同时感染SARS-CoV-2和结核病 (TB) 会增加死亡率. 了解共感染患者的免疫反应对于改善结果至关重要,因为这两种病原体都调节免疫细胞,可能会损害对COVID-19的免疫力.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 在全球范围内,SARS-CoV-2和Mycobacterium结核病 (Mtb) 是主要的传染病死亡原因.
- 同时感染COVID-19和结核病 (TB) 与死亡率增加有关.
- 在共感染个体中,SARS-CoV-2和Mtb之间的免疫相互作用需要阐明.
研究的目的:
- 为了研究对SARS-CoV-2和Mtb联合感染的免疫反应.
- 分析共感染的人类和动物模型中的免疫病理反应.
- 审查有关COVID-19和结核病共感染的临床关联和免疫调节的证据.
主要方法:
- 在PubMed和预版数据库中进行系统的文献搜索 (2020年1月以后).
- 包括研究人类和动物模型的先天性和获得性免疫反应的研究.
- 评估免疫病理反应和临床试验,包括BCG疫苗接种研究.
主要成果:
- 在高结核病负担地区,同时感染的发病率可能被低估.
- 无论是SARS-CoV-2还是Mtb都能调节关键的免疫细胞,包括单细胞,巨细胞,中性粒细胞和T细胞.
- 同时感染可能导致SARS-CoV-2免疫力受损和炎症恶化,并可能调节T细胞对Mtb.的反应.
结论:
- 由于复杂的免疫相互作用,与SARS-CoV-2和Mtb的同时感染显著影响患者的结果.
- 共同感染的免疫调节会导致炎症反应加剧和T细胞动态变化.
- 目前的证据不支持BCG疫苗接种对COVID-19的临床益处.
关键词:
细菌 卡尔梅特 盖里恩在 COVID-19 疫情中,在LTBI中,我们可以看到LTBI.在T细胞,T细胞.同时感染的同时感染.免疫反应的免疫反应.潜伏性结核病是一种潜伏性结核病.翻译学 翻译学 翻译学 翻译学更多相关视频
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