人类的阻力训练和动物的机械过载不会提高肌肉蛋白质的乳糖化
Madison L Mattingly1, Bradley A Ruple1, Casey L Sexton2
1School of Kinesiology, Auburn University, Auburn, AL, United States.
Frontiers in physiology
|October 16, 2023
概括
抵抗训练并没有增加人类或小鼠的肌肉蛋白质乳酸化,这挑战了乳酸驱动肌肉生长的想法. 这项研究发现,尽管肌肉缩,乳糖化没有显著变化.
科学领域:
- 运动生理学 运动生理学
- 分子生物学分子生物学
- 生物化学 生物化学
背景情况:
- 骨肌肉蛋白质的乳糖化被假定会随着运动而增加.
- 目前缺乏人类的经验证据.
- 乳酸在骨肌肉缩中的作用尚不清楚.
研究的目的:
- 调查急性和次慢性抵抗训练 (RT) 是否会改变人类的骨肌肉蛋白质乳酸化.
- 为了检查小鼠手术诱导的植物性肌肉缩是否会增加蛋白质乳酸化.
- 挑战乳酸促进骨肌肉缩的假设.
主要方法:
- 人类参与者接受了急性消耗性下体RT,评估了血液乳酸和巨大的侧面活检.
- 另一组人类完成了6周的下体RT,在干预前和后收集了肌肉活检.
- 小鼠接受了手术的植物性过载以诱导缩,在肌肉组织中分析了蛋白质乳糖化.
主要成果:
- 急性RT显著增加了血液中的乳酸,但没有改变细胞质或核蛋白质的乳酸化.
- 六周的RT增加了巨大的横向肌肉大小,但没有影响细胞质蛋白质的乳糖化.
- 在小鼠中,植物性肌肉缩并没有增加细胞质蛋白质的乳化;核乳化减少.
结论:
- 在人类中,急性和次慢性阻力运动似乎不会增加骨肌肉蛋白质的乳糖化.
- 在小鼠的手术诱导肌肉缩并没有提高蛋白质乳糖化.
- 目前的发现挑战了乳酸在促进骨肌肉缩中的作用.
相关概念视频
Exercise and Muscle Performance
1.5K
Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
1.5K
Muscle Recovery and Fatigue
2.2K
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
2.2K


