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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
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在患有慢性病的个体中,中风亚型
Salmi T Noor1,2, Sarah E Bota3, Anna E Clarke3
1Department of Medicine, The Ottawa Hospital, University of Ottawa, ON, Canada.
Canadian journal of kidney health and disease
|October 16, 2023
概括
慢性病 (CKD) 增加了缺血性中风风险,特别是非透析患者的心血管血栓性中风. 相反,较高的功能 (eGFR ≥60) 与较多的缺口性中风有关,这表明亚型特定的风险.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 神经学 神经学
- 流行病学 流行病学
背景情况:
- 慢性病 (CKD) 是急性缺血性中风的已知危险因素.
- 特定的缺血性中风亚型与CKD阶段之间的关联需要进一步澄清.
研究的目的:
- 研究ORG 10172在急性中风治疗 (TOAST) 试验中分类的不同缺血性中风亚型 (心血管,动脉,缺口,其他) 之间的关系.
- 评估这些中风亚型如何与慢性病 (CKD) 的各个阶段相关.
主要方法:
- 一项回顾性队列研究包括17434名在加拿大安大略省 (2002-2013) 患有急性缺血性中风的成年患者.
- 功能根据估计的淋巴细胞过率 (eGFR) 水平 (≥60,30-59,<30 mL/min/1.73 m2) 或维持透析进行分类.
- 使用TOAST标准对缺血性中风的亚型进行分类;采用调整后的回归模型.
主要成果:
- 心血管血栓性中风在非透析依赖的CKD患者中更为普遍 (eGFR 30-59和<30毫升/分钟/1.73米2).
- 性中风在患有功能减弱 (eGFR 30-59和<30毫升/分钟/1.73米2) 的患者中较少发生,而与具有eGFR ≥60毫升/分钟/1.73米2的患者相比.
- 年龄分层显示,幼年患者 (<65岁) 中的性中风更常见,老年患者 (≥65岁) 中的心性中风更常见.
结论:
- 非透析的CKD与心血管栓塞性中风的风险增加有关.
- 较高的功能 (eGFR ≥60 mL/min/1.73 m2) 与较高的缺口中风风险有关.
- 在CKD患者中,详细的中风亚型可以提供对机制的洞察力,并完善治疗策略.
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