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饮食总抗氧化能力和头癌:伊朗的一项大型病例对照研究

Fatemeh Toorang^1,2, Monireh Sadat Seyyedsalehi^1,2, Bahareh Sasanfar^1,3,4

¹Cancer Research Center, Cancer Institute, Tehran University of Medical Science, Tehran, Iran.

Frontiers in nutrition

|October 16, 2023

概括

富含抗氧化剂的饮食,以铁减少抗氧化能力 (FRAP) 和总激素捕获抗氧化剂参数 (TRAP) 衡量,显著降低头癌 (HNC) 的风险. 这项研究强调了饮食总抗氧化能力 (dTAC) 对HNC的保护作用.

科学领域:

营养科学营养科学
在瘤学瘤学.
流行病学流行病学

背景情况:

头癌 (HNC) 的病因尚不完全理解,目前有关饮食因素的数据尚不确定.
饮食总抗氧化能力 (dTAC) 的作用及其与其他风险因素在HNC发展中的相互作用以前没有被研究过.

研究的目的:

调查饮食总抗氧化能力 (dTAC) 与头癌 (HNC) 风险之间的关联.
探索dTAC与已确定的风险因素 (如烟草吸烟和片使用) 在HNC开发中的潜在相互作用.

主要方法:

一项病例控制研究,包括876名HNC患者和3,409名健康对照.
通过经过验证的食物频率问卷 (FFQ) 评估了饮食摄入量,并使用铁减少抗氧化能力 (FRAP) 和总激素捕捉抗氧化剂参数 (TRAP) 数据计算了dTAC.
使用后勤回归模型分析dTAC和HNC风险之间的关联,调整各种混因素并检查相互作用.

主要成果:

较高的dTAC分数与HNC的几率降低显著相关 (OR最高与最低三位数:FRAP和TRAP都为0.49).
针对特定的HNC亚型观察到不良关联,包括嘴唇癌和喉癌.
在dTAC (FRAP或TRAP) 和烟草吸烟或片使用之间没有发现对HNC风险的显著相互作用.

结论:

富含抗氧化剂的饮食,如FRAP和TRAP得分所示,可能在降低头癌风险方面发挥保护作用.
饮食总抗氧化能力 (dTAC) 是HNC风险及其亚型的重要逆预测因素,独立于主要风险因素.

关键词:

在FRAP中,FRAP是FRAP.这就是TRAP TRAP.案例控制研究研究.饮食中的抗氧化能力.头部和部癌症头部和部癌症

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