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对患有上皮卵巢癌的老年妇女的生存预后模型基于SEER数据库

Yingping Zhou¹, Aifen Wang¹, Xin Sun¹

¹The First Department of Gynecology, Affiliated Hospital of Chengde Medical University, Chengde, Hebei, China.

Frontiers in oncology

|October 16, 2023

概括

这项研究确定了患上上皮卵巢癌 (EOC) 的老年妇女的关键风险因素,并开发了一种预测生存率的名谱. 该模型有助于为EOC患者制定个性化治疗策略.

科学领域:

在瘤学瘤学.
老年医学老年医学
生物统计学生物统计学

背景情况:

卵巢上皮癌 (EOC) 是老年妇女的重大健康问题.
准确的预后模型对于指导临床决策和改善患者治疗结果至关重要.

研究的目的:

确定与老年妇女上皮卵巢癌 (EOC) 相关的独立风险因素.
开发和验证一种名谱,用于预测EOC的老年妇女的1年,3年和5年的整体存活期 (OS).
评估诺米图的临床适用性,用于个性化治疗计划.

主要方法:

利用了2010-2019年的SEER数据库数据,用于被诊断为EOC的70岁以上女性.
采用单变量和多因素的考克斯回归分析来确定预后因素.
为OS预测构建了一个名ogram模型,使用C指数,校准曲线和ROC分析进行验证.
通过决策曲线分析评估临床效用.

主要成果:

确定年龄,种族,婚姻状况,组织学类型,AJCC分期,分化程度,瘤参与,淋巴结状况,化疗,手术,治疗顺序和治疗时间作为独立的预后因素 (P <0.5).
达到0.749 (培训) 和0.735 (验证) 的C指数,AUC值>0.7,表明预测准确度很好.
在训练和验证集中,Nomogram表现相似,决策曲线支持其用于预测OS的临床价值.

结论:

开发的诺米图谱提供了对初始诊断时EOC的老年妇女的整体存活率的准确评估.
这种工具可以作为一个有价值的基础,为EOC患者制定个性化的临床治疗策略.

关键词:

在 SEER 数据库中,我们可以看到年长的妇女老年妇女.上皮卵巢癌卵巢癌卵巢癌这个名字是名ogramogram.预后因素预后因素

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