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向非因子治疗在血友病:一个抗血栓不敏感的Gla无域因子XA作为组织因子通路抑制剂诱

Marie-Claire Dagher1,2, Atanur Ersayin1, Landry Seyve3

  • 1Univ. Grenoble Alpes, UMR5525, CNRS, TIMC, Grenoble, France.

Research and practice in thrombosis and haemostasis
|October 16, 2023
PubMed
概括

工程设计的Gla无域XA因子变体通过抵抗抗血结合,在血友病中改善了血生成. 这些变体在缺乏FVIII的血中增强了凝血,提供了潜在的治疗策略.

关键词:
抗血素是一种抗血素.一个XA因子XA因子血友病 (hemophilia) 是一种血友病.突变发生的突变发生.组织因子通路抑制剂

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