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病例报告: 儿科患者患有晚发病的慢性疼痛

Amanda Cao¹, Raquel van Gool¹, Emma Golden¹

¹Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.

Frontiers in pain research (Lausanne, Switzerland)

|October 16, 2023

概括

晚发佩病 (LOPD) 可以导致儿童的慢性疼痛和心理症状. 与酶替代疗法 (ERT) 相结合的多学科方法对于治疗疼痛和改善生活质量至关重要.

科学领域:

生物化学生物化学
遗传学是一个遗传学.
儿科儿科儿科

背景情况:

庞培病 (PD) 是一种罕见的遗传代谢疾病,由酸α-葡萄糖酶 (GAA) 缺乏引起,导致 lysosomal glycogen分解受损.
在PD中常见的监测症状包括肌肉衰弱,呼吸系统问题和胃肠道问题.
疼痛和相关的心理症状在儿科PD患者中经常被忽视.

研究的目的:

介绍一个患有晚发佩病 (LOPD) 的儿科患者的病例,该患者经历了严重的慢性疼痛.
描述患有伴随性疼痛和心理疾病的儿童LOPD的诊断旅程和管理.
强调需要在儿科LOPD中制定全面的疼痛管理策略.

主要方法:

一个儿科患者的病例报告,在9岁时被诊断出患有LOPD.
临床评估,包括针对GAA缺乏症的基因检测.
启动用阿尔果糖酶α的酶替代疗法 (ERT).
实施多学科疼痛治疗方法,涉及骨科,物理治疗和心理治疗.

主要成果:

患者出现了从幼儿时期开始的慢性脚痛,进展到下半身疼痛,虚弱,疲劳和行走困难.
伴随性疾病包括抑郁情绪,焦虑和注意力缺陷多动障碍,可能会加剧疼痛.
除了ERT,还启动了一个多学科的疼痛管理计划.

结论:

这一案例强调了在儿科LOPD中识别和解决慢性疼痛的重要性.
与ERT集成的多学科疼痛治疗策略对于管理LOPD患者至关重要.
需要进一步的研究来优化LOPD儿童的疼痛识别和治疗方法.

关键词:

更多关于 ADHD ADHD 的文章止痛药止痛药止痛药是一种止痛药.抑郁抑郁症抑郁症抑郁症抑郁症 lysosomal 储存疾病 lysosomal 储存疾病疼痛疼痛疼痛疼痛庞贝病是庞贝病的一种疾病.

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