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对二相酸盐的急性炎症反应

L Thoraval¹, E Thiébault¹, R Siboni¹

¹Université de Reims Champagne-Ardenne, EA4691 "Biomatériaux et Inflammation en site osseux" BIOS, Reims, France.

Materials today. Bio

|October 16, 2023

概括

铜二相酸盐 (BCP) 生物材料的化增强了中性粒细胞的招募和特定的炎症标志物. 这种骨免疫调节效应表明了改善骨重建和感染控制的潜力.

科学领域:

生物材料科学生物材料科学
免疫学免疫学免疫学
整形外科整形外科整形外科

背景情况:

骨植入生物材料的消毒和无菌松动通常与感染和炎症有关.
调节免疫和骨细胞交叉对改善生物材料性能至关重要.
酸盐的阴位兴奋剂提供了一种控制生物材料诱导的炎症和增强骨免疫调节特性的策略.

研究的目的:

合成和研究铜(II) 离子化双相酸盐 (BCP) 生物材料的骨免疫调节性质.
评估人类初级多态核中性粒细胞 (PMN) 对化和未化BCP的体外炎症反应.
用小鼠气囊模型评估体内炎症效应和PMN招募.

主要方法:

通过湿法合成铜 (II) 离子化和未化BCP粉末.
在体外分析PMN炎症反应使用ELISA和血脉图,有或没有LPS刺激.
在实体中评估PMN在小鼠气囊模型中的招募,使用流细胞计.

主要成果:

配铜的BCP显著增加了PMN的IL-8和GRO-α分泌in vitro,但没有影响MIP-1β,TNF-α或MMP-9.
在体内研究表明,与未使用的BCP相比,使用铜 (II) 兴奋剂BCP的PMN招募增加.
该材料表现出特定的骨质免疫调节效应,调节炎症环境.

结论:

铜 (II) 注BCP有效调节中性粒细胞的炎症反应.
诱导的中度炎症可能会增强细菌清除,补充材料的抗菌潜力.
用铜合的BCP通过微调炎症环境,为假肢涂层和骨重建提供了有前途的应用.

关键词:

生物材料是一种生物材料.Cu-doped 双相酸二酸盐的使用方法细胞因子 (cytokines) 是一种细胞因子.炎症炎症是一种炎症.网症 (NETosis) 是一种疾病.

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