在临床上处于精神病高风险的个体中,前述加速体积变化的微结构性皮层灰质变化
Ik Cho Kang1, Ofer Pasternak1, Fan Zhang2
1Harvard Medical School.
Research square
|October 16, 2023
概括
通过扩散MRI检测到的微结构灰质变化比临床精神病高风险个体的体积减少更为普遍. 这些早期变化在精神病发作之前发生,并可能有助于早期发现.
科学领域:
- 神经成像是一种神经成像.
- 精神病学是一个精神病学.
- 神经科学是一个神经科学.
背景情况:
- 在患有精神病临床高风险 (CHR) 的人群中,加速的灰质量 (GM) 体积减少与精神病的发展有关.
- 这种体积减少可能源于潜在的微观结构变化,表明神经退行.
- 早期发现这些微观结构变化对于理解和潜在地干预精神病发展至关重要.
研究的目的:
- 在CHR的个人中使用扩散MRI (dMRI) 检测微结构GM变化.
- 调查基线和纵向差异的基因转基因微观结构和量之间的CHR个体和健康的对照 (HC).
- 确定这些dMRI测量是否可以区分患有精神病的CHR个体 (CHR-P) 和不患精神病的人 (CHR-NP).
主要方法:
- 利用了来自160名CHR个体和96名HC的DMRI和解剖MRI数据.
- 检查了八个皮层叶片的GM体积和微观结构.
- 使用间歇性自由水 (IFW),一种新的dMRI测量方法,通过排除脑脊液影响来量化GM微观结构.
主要成果:
- 在基线时,CHR个体在多叶相比HC显示出更高的IFW,而GM体积减少仅在叶显著.
- 无论是IFW还是基线体积都没有将CHR-P与CHR-NP区分开来.
- 与CHR-NP组相比,CHR-P组表现出明显加速的IFW增加和体积减少.
结论:
- 在CHR个体中,微观结构的转基因变化 (更高的IFW) 比体积变化更为广泛.
- 这些微观结构的改变先于在精神病发作时观察到的加速的大脑变化.
- 基于dMRI的微观结构变化代表了精神病症的前阶段的早期病理,对早期检测和机理理解有潜在的价值.
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