患有输血依赖性沙拉西米亚的患者的并发症:一个描述性的横截面研究
Mohammad Faranoush1,2, Pooya Faranoush1,3, Iraj Heydari1
1Pediatric Growth and Development Research Center, Institute of Endocrinology Iran University of Medical Sciences Tehran Iran.
在β-thalassemia患者中,铁过载与器官损伤有显著的相关性,包括肺动脉压力增加和射出分数减少. 早期检测和多学科护理对于改善患者的治疗结果和生活质量至关重要.
科学领域:
- 血液学 血液学 血液学
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 骨的新陈代谢 骨的新陈代谢
背景情况:
- thalassemia综合征是全球常见的血红蛋白病,经常导致输血导致的铁过载.
- 患有输血依赖性β-thalassemia的患者的费里丁水平升高可能会导致严重的器官损伤.
- 了解对重要器官铁过载的并发症对于患者管理至关重要.
研究的目的:
- 评估血液输血依赖性β-thalassemia患者对重要器官铁过载的并发症.
- 为了确定费里水平和各种器官功能标志物之间的相关性.
主要方法:
- 在1010名患有β-thalassemia major. 的患者中进行了一项描述性的横截面研究.
- 评估包括血液学分析,心声回声 (PAP,EF),骨密度计和听力测试.
- 关于费里水平的数据与各种临床和生化参数相关.
主要成果:
- 升高的费里水平与增加的甘油三,,甲状腺刺激激素,性酸酶,氨酸转胺酶和肺动脉压力 (PAP) 有显著的相关性.
- 铁过载与年龄,听力障碍,脊髓切除术,骨质疏松症,高密度脂蛋白,体重指数,和排泄分数 (EF) 的下降有关.
- 没有发现费里水平与性别,胆固醇,LDL,PTH或T4之间有显著的相关性.
结论:
- 多学科的护理,定期的随访和早期的并发症检测可以改善β-thalassemia患者的生存率和生活质量.
- 该研究强调了铁过载对该患者群体多个器官系统的广泛影响.
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Published on: September 6, 2017
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